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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract: ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2GP I complex.Platelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression andactivate platelets, and this activation was inhibited by either the anti-GP I bα antibody or theactivation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: In our study, we found by qRT-PCR that miR-148b was significantly upregulated in sheep wool follicleOverexpression of miR-148b promoted proliferation of both HHDPC and HHGMC.By using the TOPFlash system we demonstrated that miR-148b could activate Wnt/β-catenin pathway andfactor nuclear factor of activated T cells type 5 ( ) and were predicted to be the target of miR-148bSubsequently was further identified as the target of miR-148b using western blotting.

Keywords： miR-148b     hair follicle     proliferation     <i>NFAT5i>     <i>Wnt10bi>    

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Inhibition of NO emission by adding antioxidant mixture in

B. ANAND

Frontiers in Energy 2015, Volume 9, Issue 2,   Pages 238-245 doi: 10.1007/s11708-015-0356-8

Abstract: In this paper, the effect of adding an antioxidant mixture in biodiesel as fuel, in a single cylinder, direct injection compression ignition engine was experimentally investigated and the level of pollutants in the exhaust and performance characteristics of the engine were analyzed. Nine test fuels were prepared with three antioxidants, namely, Succinimide (C H NO ), , dimethyl- -phenylenediamine-dihydrochloride (C H Cl N ), and -phenyl- -phenylenediamine (C H NHC H NH ) added to neat biodiesel at 500 parts per million (ppm), 1000 ppm and 2000 ppm and the observed experimental results were compared with those of neat biodiesel and neat diesel as base fuels. The comparison showed that NO emission was reduced drastically for the test fuels with the antioxidant addition of 2000 ppm. The maximum reduction of 10% of NO emission was observed for the antioxidant mixture in neat biodiesel, with a slight increase in unburned HC, CO and smoke opacity. In addition, the obtained experimental results reveal that the addition of two antioxidants as mixture in neat biodiesel caused improved NO emission reduction for all test fuels.

Keywords： NO emission     antioxidants     Succinimide     <i>Ni>     <i>Ni>-dimethyl-<i>pi>-phenylenediamine-dihydrochloride     <i>Ni>-phenyl-<i>pi>-phenylenediamine    

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Presentation of regression analysis, GP and GMDH models to predict the pedestrian density in various

Iraj BARGEGOL; Seyed Mohsen HOSSEINIAN; Vahid NAJAFI MOGHADDAM GILANI; Mohammad NIKOOKAR; Alireza OROUEI

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 2,   Pages 250-265 doi: 10.1007/s11709-021-0785-x

Abstract: In this study, the relationship between space mean speed (<i>SMSi>), flow rate and density of pedestriansRegression analysis was then applied to determine the relationship between <i>SMSi>, flow rate, andFinally, two prediction models of density were obtained using genetic programming (GP) and group methodResults also indicated that GP had a higher <i>Ri>2 than GMDH in the prediction of pedestriandensity in terms of flow rate and <i>SMSi>, suggesting that GP was better able to model <i>SMSi>

Keywords： pedestrian density     regression analysis     GP model     GMDH model    

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Thermal and Mechanical Properties Optimization of <i>ABi>O4 Type EuNbO4 By the<i>Bi>-Site Substitution of Ta Article

Lin Chen, Jing Feng

Engineering 2020, Volume 6, Issue 2,   Pages 177-184 doi: 10.1016/j.eng.2019.12.006

Abstract: In this work, B-site substitution of tantalum (Ta) is used to optimize the thermal and mechanicalthat the thermal and mechanical properties of EuNbO4 can be effectually optimized via the B-site

Keywords： Thermal barrier coatings     Rare earth niobates     Substitution     Thermal conductivity     Thermal expansion coefficients     Young’s modulus    

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supported polyhedral NiS/NiS nanocrystals with excellent photocatalytic performance for removing rhodamine B

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 6,   Pages 1537-1549 doi: 10.1007/s11705-021-2094-2

Abstract: Hence, photoreduction of Cr(VI) to Cr(III) and degradation of rhodamine B (RhB) using a novel photocatalystIn this work, <i>hi>-BN/NiS2/NiS composites were prepared via a simple solvothermal methodThe 7 wt-% <i>hi>-BN/NiS2/NiS composites were characterized via a larger specific surfaceThe experimental result indicated that the photoreduction efficiency of the 7 wt-% <i>hi>-BN/NiSi>-BN promoted transportation of photoinduced charges on the surface of the <i>hi>-BN/NiS2<

Keywords： graphene-like <i>hi>-BN     <i>hi>-BN/NiS2/NiS composites     photocatalysis     Cr(VI) reduction    

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NiBO (B = Mn or Co) catalysts for NH-SCR of NO at low-temperature in microwave field

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 8, doi: 10.1007/s11783-023-1696-y

Abstract:

● Microwave-assisted catalytic NH3-SCR reaction over spinel oxides is carried out.

Keywords： Microwave field     Spinel oxides     NO<i>xi>     Selective catalytic reduction    

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Association of gene variants with juvenile amyotrophic lateral sclerosis

Frontiers of Medicine doi: 10.1007/s11684-023-1005-y

Abstract: A variation within <i>TRMT2Bi> (c.1356G>T; p.K452N) was identified to be associated with ALS in a familya high level of ROS were observed functionally in patient-originated lymphoblastoid cell lines and <i>TRMT2Bi> interfering HEK293 cells.Further, <i>TRMT2Bi> variations overexpression cells also displayed decreased ND1.In conclusion, a novel JALS-associated gene called <i>TRMT2Bi> was identified, thus broadening the

Keywords： <i>TRMT2Bi>     amyotrophic lateral sclerosis     mitochondrial complex I     tRNA methylation     reactive oxygen    

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Elasto-plastic fatigue crack growth analysis of plane problems in the presence of flaws using XFEM

SHEDBALE,I. V. SINGH,B. K. MISHRA

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 4,   Pages 420-440 doi: 10.1007/s11709-015-0305-y

Abstract: The -integral for two fracture modes (mode-I and mode-II) is obtained by decomposing the displacement

Keywords： XFEM     von-Mises yield criterion     isotropic hardening     fatigue crack growth     <i>Ji>-integral    

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Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse largeB-cell lymphoma in Chinese patients

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 285-294 doi: 10.1007/s11684-021-0843-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR) T cell therapy has shown impressive efficacy in treating B-cellA single-center phase I dose-escalation study was conducted to evaluate the safety and efficacy of TCAR bearing 4-1BB costimulatory molecule, for the treatment of patients with refractory diffuse large B-cell

Keywords： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limiting    

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End-use energy utilization efficiency of Nigerian residential sector

Fidelis I. ABAM,Olayinka S. OHUNAKIN,Bethrand N. NWANKWOJIKE,Ekwe B. EKWE

Frontiers in Energy 2014, Volume 8, Issue 3,   Pages 322-334 doi: 10.1007/s11708-014-0329-3

Abstract: In this paper, the end-use efficiencies of the different energy carriers and the overall energy efficiency in the Nigerian residential sector (NRS) were estimated using energy and exergy analysis. The energy and exergy flows were considered from 2006 to 2011. The overall energy efficiency ranges from 19.15% in 2006 to 20.19% in 2011 with a mean of (19.96±0.23)% while the overall exergy efficiency ranges from 4.34% in 2006 to 4.40% in 2011 with a mean of (4.31±0.059)%. The energy and exergy efficiency margin was 15.58% with a marginal improvement of 0.07% and 0.02%, respectively when compared with previous results. The contribution of the energy carriers to the total energy and exergy inputs were 1.45% and 1.43% for electricity, 1.95% and 3% for fossil fuel and 96.6% and 95.57% for bio-fuel. The result shows that approximately 65% of the residence use wood and biomass for domestic cooking and heating, and only a fraction of the residence have access to electricity. LPG was found to be the most efficient while kerosene, charcoal, wood and other biomass the least in this order. Electricity utilization exergy efficiency is affected by vapor-compression air conditioning application apart from low potential energy applications. In addition, this paper has suggested alternatives in the end-use application and has demonstrated the relevance of exergy analysis in enhancing sustainable energy policies and management and improved integration techniques.

Keywords： end-use     energy     exergy efficiency     residential sector     Nigeria    

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Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 232-237 doi: 10.1007/s11705-012-1286-1

Abstract: Ninety male Wistar rats were selected under the “Guide for the Care and Use of Laboratory Animals” for skin-muscle wound models. Three groups of animals were examined respectively for inoculation of inhibitor of p38 MAPK (mitogen activated protein kinase) SB 203580 and JNK inhibitor SP 600125, and a control. Light microscopy, immunohistochemistry, and tensometry revealed that the inhibition of p38 or JNK cascades have modified the formation of the connective tissue scar. The degree of connective tissue growth in the area of surgical wound had been significantly reduced by the end of observation (30 d) as the SB 203580 was applied (% volume of collagen 43.60 (41.05 – 60.15) 73.54 (66.87 – 78.01) in control, = 0.002). Conversely, when we have applied the JNK blocker, the density of collagen in scar tissue increased (78.14 (72.77 – 81.14), = 0.022 control). SB203580 inhibits the expression of p38, c-Jun and c-Fos. When we have used the JNK blocker, the expression of c-Fos and c-Jun decreased, but the expression of p38 increased. This determines the high functional activity of fibroblasts after using SP 600125. Obtained results show the importance of studying regulators of cell differentiation as potential drugs, which significantly affect the outcome of the pathological processes.

Keywords： connective tissue     mitogen activated protein kinase (MAPK)     p38     JNK    

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Trihydrazinotriazine-grafting Fe

Jamal Rahimi, Seyedeh Shadi Mirmohammadi, Ali Maleki

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 4,   Pages 1008-1020 doi: 10.1007/s11705-020-1996-8

Abstract: This study focuses on the synthesis and characterization of a novel magnetic nanocomposite 2,4,6-trihydrazino-1,3,5-triazine (THDT)-functionalized with silica-coated iron oxide magnetic nanoparticles (MNPs). This nanocomposite has porous morphology decorated with the spherical MNPs. Through co-precipitation of iron salts, MNPs were obtained. The prepared THDT was placed on the chlorine surface-modified MNPs. The present environment-friendly nanocatalyst intensely accelerated the synthesis of highly functionalized tetrahydrobenzo[ ]pyran derivatives as well as reduced the reaction times and increased yields of the products.

Keywords： trihydrazino-triazine     porous     magnetic nanocatalyst     green chemistry     tetrahydrobenzo[<i>bi>]pyrans    

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Expression of heat shock protein gp96 in osteosarcoma and its clinical significance

GUO Weichun, CHEN Anmin

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 200-203 doi: 10.1007/s11684-008-0038-6

Abstract: This study aims to detect the expression of heat shock protein gp96 (HSPgp96) in osteosarcoma and explore
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Antifungal and antibacterial functions of medicinal leech recombinant destabilase-lysozyme and its heated-up derivative

PISKUNKOVA, I. B. PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 203-209 doi: 10.1007/s11705-012-1277-2

Abstract: Antifungal activity of recombinant medicinal leech destabilase-lysozyme (rec.Dest-Lys) was investigated by using fungi: , and , including yeasts and . Its antibacterial activity was investigated on gram-negative bacteria . These activities were assessed by radial agar diffusion assay, and scanning and transmission electron microscopy. Therefore, destabilase-lysozyme not only is endo-isopeptidase and lysozyme, but also has antifungal and antibacterial activities. Muramidase activity of rec.Dest-Lys disappeared after heat-treating at 90°C for 50 min without the loss of its antimicrobial activity. Furthermore we showed for the first time that the heated-up derivative of rec.Dest-Lys exhibited more potent activities against the above enumerated fungi and gram-negative bacteria than original protein.

Keywords： recombinant destabilase-lysozyme (rec.Dest-Lys)     antimicrobial activity     antifungal activity     medicinal leech     heated-up derivative of rec.Dest-Lys (T-rec.Dest-Lys)    

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Title Author Date Type Operation

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

Inhibition of NO emission by adding antioxidant mixture in

B. ANAND

Journal Article

Presentation of regression analysis, GP and GMDH models to predict the pedestrian density in various

Iraj BARGEGOL; Seyed Mohsen HOSSEINIAN; Vahid NAJAFI MOGHADDAM GILANI; Mohammad NIKOOKAR; Alireza OROUEI

Journal Article

Thermal and Mechanical Properties Optimization of <i>ABi>O4 Type EuNbO4 By the<i>Bi>-Site Substitution of Ta

Lin Chen, Jing Feng

Journal Article

supported polyhedral NiS/NiS nanocrystals with excellent photocatalytic performance for removing rhodamine B

Journal Article

NiBO (B = Mn or Co) catalysts for NH-SCR of NO at low-temperature in microwave field

Journal Article

Association of gene variants with juvenile amyotrophic lateral sclerosis

Journal Article

Elasto-plastic fatigue crack growth analysis of plane problems in the presence of flaws using XFEM

SHEDBALE,I. V. SINGH,B. K. MISHRA

Journal Article

Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse largeB-cell lymphoma in Chinese patients

Journal Article

End-use energy utilization efficiency of Nigerian residential sector

Fidelis I. ABAM,Olayinka S. OHUNAKIN,Bethrand N. NWANKWOJIKE,Ekwe B. EKWE

Journal Article

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Journal Article

Trihydrazinotriazine-grafting Fe

Jamal Rahimi, Seyedeh Shadi Mirmohammadi, Ali Maleki

Journal Article

Expression of heat shock protein gp96 in osteosarcoma and its clinical significance

GUO Weichun, CHEN Anmin

Journal Article

Antifungal and antibacterial functions of medicinal leech recombinant destabilase-lysozyme and its heated-up derivative

PISKUNKOVA, I. B. PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA

Journal Article